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Supplementation Of Culture Media With Zwitterionic Buffers Supports Sperm Function And Embryo Development Within The Elevated CO2 Levels Of The Laboratory Incubator

Maintenance of a stable media pH used for gamete and embryo culture in clinical IVF is crucial for the proper functionality of various intracellular signaling pathways and biochemical processes which can dramatically impact subsequent embryo development. Current culture media are pH buffered using NaHCO3, which gives the desired pH within the elevated CO2 environment of the incubator. However, NaHCO3 is a weak buffer and can result in dramatic pH shifts outside the incubator. Therefore, improved buffering capacity of culture media, more resistant to perturbations…

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