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A comparison of day-3 versus day-2 and day-5 versus day-4 embryo transfers among in-vitro fertilization patients
Introduction
Since the start of in vitro fertilization (IVF), embryos have been transferred 2 days after IVF at the 2 to 4 cell stage. This policy was adopted because of lack of suitable culture media able to sustain embryonic development for several days, hence the uterus was supposed to provide the best environment for embryo survival.
The timing of the arrival of the embryo in the uterus however is premature compared with in-vivo situations, where the embryo enters the uterus at the morula stage 4 – 5 days after ovulation (1)….
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