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In-Vited Commentary: Improving Human IVF Success Requires Basic Research with Animal Models

The successful application of IVF/ART to treat human infertility is now over 30 years old. Remarkable improvements to the technology have occurred during the past two decades, notably ultrasound-guided aspiration of ovarian follicle contents, customized stimulation regimens using recombinant gonadotropins, and culture media formulations that better reflect the needs of embryos. As a result, success rates have climbed rapidly since the beginning of clinical IVF: the U.S. average live birth rate in 2007 using fresh, non-donor embryos was 46% per transfer for…

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