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In Vitro Culture of Human Embryos: Effect of Oxygen Tension on Resulting Offspring

Introduction
Embryos derived from in vitro culture with the use of various O2 tensions have been shown to produce offspring with altered birth weights. For example, bovine embryos cultured in vitro with 5% O2 have been shown to yield calves with smaller birth weights than embryos cultured in 20% O2 (1).

Multiple factors involved in the in vitro culture setting have shown connections to Large Offspring Syndrome (LOS) in ovine and bovine, which includes…

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