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Mechanism of Human Gonadal Differentiation in Early Fetal Development

Human Fetal gonadal differentiation is a very com- plicated series of events actively programmed at appropriate critical periods of fetal life, which involves both genetic and hormonal factors leading to the sexual dimorphism observed at birth. This fundamental dif- ference is essential for sexual reproduction (Lim et al. 1998b). Our understanding of how these differences are brought about is far from complete.

So far, whatever knowledge we do have of human genital tract formation, largely comes from information…

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